Mood Disorders

Arch Clinical Trials is currently recruiting participants between the ages of 16 and 40 who have been diagnosed with bipolar 1 disoder in the last four years, and who have had low exposure to antipsychotics and mood stabilizers. For more information, call 314-282-3521 or visit www.archclinicaltrials.com.

St. Louis Clinical Trials conducts ongoing trials for various conditions, including bipolar. Please visit www.stlclinicaltrials.com or call 314-802-8822 for more information.

Psychiatric Care and Research Center conducts ongoing trials for various diagnoses, including bipolar disorder in adults. Visit www.pcrc-stl.com or call 636-244-3593 for more information.

Midwest Research Group/St. Charles Psychiatric Associates is conducting a clinical trial of medication for adults aged 18 to 65 who are diagnosed with Bipolar I. This study utilizes cariprazine to evaluate its effectiveness for adults experiencing mania or depression. Participants will receive this medication in prevention of relapse.

Participants will receive study medication or placebo, physician consultation, travel expenses and compensation for their time.  No insurance required.

Please visit MidwestResearchGroup.com or call 636-946-8032 and speak with Nicole or text 636-486-1930 and complete a short form.

Midwest Research Group     4801 Weldon Spring Parkway #300     St. Charles, MO 63304

PsychCare Consultants Research LLC is enrolling participants who have Bipolar disorder and experience mild to moderation agitation. Participation consists of a one-time inhaled dose of medication. For more information, call Toni Ransdell at 314-608-8781 or Syed Zaidi at 314-616-7071 or 314-849-1853 Ext. 206.

Washington University is looking for individuals to participate in a research study that examines thinking and memory. Some of the participation criteria includes being diagnosed with Bipolar Disorder, currently taking medication for this disorder, and being between the ages of 18 and 55. For more information, contact Lori at 314-747-6175.

Midwest Research Group/St. Charles Psychiatric Associates is conducting four (4) clinical trials of medications for adults, age 18 and older, who are diagnosed with depression.

  • Study #1 is for adults who continue to have depressive symptoms even after trying at least one antidepressant medication. All participants are guaranteed to receive an open-label, approved antidepressant medication. An add-on medication will be provided with the goal of decreasing depressive symptoms and increasing energy levels.
  • Study #2 is for adults with treatment-resistant depression, meaning they have tried several different medications and “nothing seems to work.” This study only lasts three weeks and includes coming into the office three times a week.
  • Study #3 focuses on people with treatment resistant depression who either are taking an antidepressant medication or not. It is a novel medication thought to combat depression in a different way than conventional medications.
  • Study #4 is for adults that are stable on an antidepressant and things are going well. It requires participants to complete surveys about their depression and complete tasks that measure cognition. This study requires 3-5 study visits and pays $75 each time.

Participants in this study will receive study medication or placebo, physician consultation, travel expenses and compensation for their time. No insurance required.

Please visit MidwestResearchGroup.com or call 636-946-8032 and speak with Nicole or text 636-486-1930 and complete a short form.

Midwest Research Group     4801 Weldon Spring Parkway #300     St. Charles, MO 63304

Psychiatric Care and Research Center conducts ongoing trials for various diagnoses, including depression in adults. Visit www.pcrc-stl.com or call 636-244-3593 for more information.

St. Louis Clinical Trials conducts ongoing trials for various conditions, including depression. Please visit www.stlclinicaltrials.com or call 314-802-8822 for more information.

Kites is a clinical research study that will investigate the safety and effectiveness of an investigational medicinal product for major depression in young people aged from 7 to 17. Participants will also have five sessions of talk therapy (up to 30 minutes) with one of the study team doctors. Numerous study sites across the nation, including the St. Louis area.

For more information, click here.

Midwest Research Group/St. Charles Psychiatric Associates is conducting a clinical trial of medication for children ages 7 to 17 who are diagnosed with depression. This study compares two approved antidepressant medications (one approved for adults and one approved for children) to see which one works better. Children in this study also receive counseling services at no cost. Participants interested in this study must have suffered from depressive symptoms for the last six weeks and are looking for an alternative medication.

Participants in this study may receive study medication or placebo, physician consultation, travel expenses and compensation for their time.  No insurance required.

Please visit MidwestResearchGroup.com or call 636-946-8032 and speak with Nicole or text 636-486-1930 and complete a short form.

Midwest Research Group     4801 Weldon Spring Parkway #300     St. Charles, MO 63304

Have you experienced two or more periods of feeling sad, down, or depressed in your life, or simply feeling not interested in activities you usually enjoy doing? These periods may range from two weeks to months or years. If you have these experiences, you might be eligible to participate in the Emotion & Mental Health Lab at Washington University's study which explores how people think, feel, and make decisions. There are three parts to the study:

  • An online survey (about 30 min)
  • Laboratory session (1-2 hours)
  • Brief cell phone surveys (5 surveys a day for 2 weeks)

The study involves completing an online survey and attending a laboratory session, which consists of an interview determining eligibility for the remaining parts of the study. Those who are eligible will be invited to complete another online survey and a tutorial at the laboratory session, as well as brief cell phone surveys about their emotions, thoughts, and decision-making in the two weeks following the laboratory session. This is a paid study. In addition to the emotional experiences, other eligibility criteria include:

  • Participants must be between 38 and 77 years old
  • Speak English as your primary language

For more information, call 314-935-3502 or email This email address is being protected from spambots. You need JavaScript enabled to view it..

Midwest Research Group/St. Charles Psychiatric Associates is conducting a clinical trial of medication for women between the ages of 18 and 45 who are diagnosed with Post-partum Depression. This study site is one of ten in the country using Brexanolone, a neural steroid which helps to replace the drop in allopregnanolone levels which are known to occur post-partum. This medication has been granted Breakthrough Therapy designation by the FDA. 

Participants must be less than 6 months post-partum, and experienced depression onset that began no earlier than the third trimester and no later than the first four weeks following delivery.

Participants in this study may receive study medication or placebo, physician consultation, travel expenses and compensation for their time.  No insurance required.

Please visit MidwestResearchGroup.com or call 636-946-8032 and speak with Nicole or text 636-486-1930 and complete a short form.

Midwest Research Group     4801 Weldon Spring Parkway #300     St. Charles, MO 63304

Dr. Charles Conway at Washington University is study studying the use of a genetic tool to improve outcomes for individuals who have never taken an antidepressant. The tool classifies the likelihood to respond to antidepressants. Initial criteria includes:

  • Age 18 to 65 
  • Currently experience depression
  • Have never taken medication for depression
  • No history of schizophrenia or bipolar disorder
  • No history of gastric bypass surgery

For more information, call 314-273-1921.

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